Title: Cobrotoxin
CAS Registry Number: 12584-83-7
Literature References: The main toxic protein in cobra venom. Crystallization and properties: Yang, J. Biol. Chem. 240, 1616 (1965). Composed of a single peptide chain having 62 amino acid residues intramolecularly cross-linked by four disulfide bonds. Amino acid sequence: Yang et al., Biochim. Biophys. Acta 188, 65 (1969). Complete structure: eidem, ibid. 214, 355 (1970). Synthetic study: H. Aoyagi et al., ibid. 263, 823 (1972). Review: C. C. Yang, "Biochemical Studies on the Toxic Nature of Snake Venom Cobrotoxin from Formosan Cobra Venom" in Toxins of Animal and Plant Origin I, A. de Vries, E. Kochva, Eds. (Gordon and Breach Science Publishers, New York, 1971) pp 205-236. See also A. T. Tu, Venoms: Chemistry and Molecular Biology (John Wiley and Sons, New York, 1977) pp 174-189. |