Cloxyquin
Title: Cloxyquin
CAS Registry Number: 130-16-5
CAS Name: 5-Chloro-8-quinolinol
Additional Names: 5-chloro-8-hydroxyquinoline; 5-chloro-8-oxychinolin; cloxiquine
Trademarks: Chlorisept (Chinosolfabrik)
Molecular Formula: C9H6ClNO
Molecular Weight: 179.60
Percent Composition: C 60.19%, H 3.37%, Cl 19.74%, N 7.80%, O 8.91%
Literature References: Prepn: Bratz, Niementowski, Ber. 52, 189 (1919); Weizmann, Bograchov, J. Am. Chem. Soc. 69, 1222 (1947); Manske et al., Can. J. Res. 27F, 359 (1949). Crystal structure: T. Banerjee, N. N. Saha, Acta Crystallogr. C42, 1408 (1986).
Properties: Crystals from ethanol, mp 130°. Sparingly sol in cold, dil HCl.
Melting point: mp 130°
 
Derivative Type: Hydrochloride
Molecular Formula: C9H6ClNO.HCl
Molecular Weight: 216.06
Percent Composition: C 50.03%, H 3.27%, Cl 32.82%, N 6.48%, O 7.41%
Properties: Yellow needles. mp 256-258°.
Melting point: mp 256-258°
 
Derivative Type: Acetate (ester)
Additional Names: 5-Chloro-8-acetoxyquinoline
Molecular Formula: C11H8ClNO2
Molecular Weight: 221.64
Percent Composition: C 59.61%, H 3.64%, Cl 16.00%, N 6.32%, O 14.44%
 
Therap-Cat: Antibacterial; antifungal.
Keywords: Antifungal (Synthetic); Antiseptic/Disinfectant; Quinolines.

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