Title: Captodiamine
CAS Registry Number: 486-17-9
CAS Name: 2-[[[4-(Butylthio)phenyl]phenylmethyl]thio]-N,N-dimethylethanamine
Additional Names: 2-[p-(butylthio)-a-phenylbenzylthio]-N,N-dimethylethylamine; p-butylmercaptobenzhydryl b-dimethylaminoethyl sulfide; p-butylthiodiphenylmethyl 2-dimethylaminoethyl sulfide; captodiam; captodramin
Molecular Formula: C21H29NS2
Molecular Weight: 359.59
Percent Composition: C 70.14%, H 8.13%, N 3.90%, S 17.83%
Literature References: Prepn: Hübner, Petersen, US 2830088 (1958). Pharmacological studies: R. Kopf, I. Moller-Nielsen, Arzneim.-Forsch. 8, 154 (1958).
Derivative Type: Hydrochloride
CAS Registry Number: 904-04-1
Trademarks: Covatine (Bailly); Covatix (Gecke); Suvren (Ayerst)
Molecular Formula: C21H29NS2.HCl
Molecular Weight: 396.05
Percent Composition: C 63.69%, H 7.63%, N 3.54%, S 16.19%, Cl 8.95%
Properties: Crystals, mp 131-132°. LD50 (96 hr) in mice, rats (mg/kg): 180, 343 i.p.; 1630, 3800 orally (Kopf, Moller-Nielsen).
Melting point: mp 131-132°
Toxicity data: LD50 (96 hr) in mice, rats (mg/kg): 180, 343 i.p.; 1630, 3800 orally (Kopf, Moller-Nielsen)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic. |