Bottromycin

Literature References: A complex of five antibiotics of which the main active component is bottromycin A2. Produced by Streptomyces bottropensis and S. canadensis: Waisvisz et al., J. Am. Chem. Soc. 79, 4520, 4522, 4524 (1957); Miller et al., Antimicrob. Agents Chemother. 1967, 407. Production: GB 762736 (1956 to Koninklijke Nederlandsche Gist en Spiritus-Fabriek); Umesawa et al., JP 68 10998 (1968 to Microbiochem. Res. Found.), C.A. 69, 85439x (1968); Hata et al., US 3650904 (1972). Partial structure: Waisvisz, Hoeven, J. Am. Chem. Soc. 80, 38 (1958). Sepn and structures of bottromycins A1, A2, and B: Nakamura et al., J. Antibiot. 18A, 47, 60 (1965); 19A, 10 (1966). Isoln and characterization of bottromycins A2, B2, C2: Nakamura et al., ibid. 20A, 1 (1967). Revised structure of bottromycin A2: Takahashi et al., ibid. 29A, 1120 (1976); D. Schipper, ibid. 36A, 1076 (1983). Mode of action of bottromycin A2: T. Otaka, A. Kaji, J. Biol. Chem. 251, 2299 (1976); eidem, FEBS Lett. 123, 173 (1981).