Title: Arbutamine
CAS Registry Number: 128470-16-6
CAS Name: 4-[(1R)-1-Hydroxy-2-[[4-(4-hydroxyphenyl)butyl]amino]ethyl]-1,2-benzenediol
Additional Names: (R)-3,4-dihydroxy-a-[[[4-(p-hydroxyphenyl)butyl]amino]methyl]benzyl alcohol; 1-(3,4-dihydroxyphenyl)-2-(4-(4-hydroxyphenyl)butylamino)ethanol
Molecular Formula: C18H23NO4
Molecular Weight: 317.38
Percent Composition: C 68.12%, H 7.30%, N 4.41%, O 20.16%
Literature References: Catecholamine cardiac stimulant. Prepn: R. R. Tuttle, C. E. Browne, III, EP 329464; eidem, US 5395970 (1989, 1995 both to Gensia). Pharmacology and pharmacodynamics: M. Young et al., Drug Dev. Res. 32, 19 (1994). Efficacy as exercise stimulating agent (ESA) in comparison with dobutamine, q.v.: H. K. Hammond, M. D. McKirnan, J. Am. Coll. Cardiol. 23, 475 (1994).
Derivative Type: Hydrochloride
CAS Registry Number: 125251-66-3
Manufacturers' Codes: GP-2-121-3
Trademarks: GenESA (Gensia)
Properties: Off-white, amorphous solid. mp 55-58°. [a]D23 -18.5° (in ethanol). Freely sol in water, ethanol. Practically insol in diethyl ether, hexane.
Melting point: mp 55-58°
Optical Rotation: [a]D23 -18.5° (in ethanol)
Therap-Cat: Stress agent for diagnosis of coronary artery disease.
Keywords: Diagnostic Aid. |