Title: Alfentanil
CAS Registry Number: 71195-58-9
CAS Name: N-[1-[2-(4-Ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide
Additional Names: N-[1-[2-(4-ethyl-5-oxo-2-tetrazolin-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]propionanilide
Molecular Formula: C21H32N6O3
Molecular Weight: 416.52
Percent Composition: C 60.56%, H 7.74%, N 20.18%, O 11.52%
Literature References: Tetrazole derivative of fentanyl, q.v. Prepn: F. Janssens, DE 2819873; idem, US 4167574 (1978, 1979 both to Janssen); F. Janssens et al., J. Med. Chem. 29, 2290 (1986). Determn in human plasma by GC: T. J. Gillespie et al., J. Anal. Toxicol. 5, 133 (1981); by radioimmunoassay: M. Michaels et al., J. Pharm. Pharmacol. 35, 86 (1983). Pharmacology in animals: C. J. E. Niemegeers, P. A. J. Janssen, Drug Dev. Res. 1, 83 (1981); in humans: B. Kay, B. Pleuvry, Anaesthesia 35, 952 (1980). Cardiovascular effects during surgery: P. S. Sebel et al., Br. J. Anaesth. 54, 1185 (1982). Clinical evaluation as analgesic component of anesthesia: B. Kay et al., Ann. R. Coll. Surg. Engl. 65, 316 (1983); as anesthetic induction agent: J. Nauta et al., Anesth. Analg. 61, 267 (1982); M. E. Sinclair, G. M. Cooper, Anaesthesia 38, 435 (1983). Review of clinical pharmacokinetics: L. E. Mather, Clin. Pharmacokinet. 8, 422 (1983); of clinical trials of alfentanil and sufentanil: S. De Lange, Mt. Sinai J. Med. 50, 312 (1983).
Derivative Type: Hydrochloride monohydrate
CAS Registry Number: 70879-28-6
Additional Names: Alfentanil hydrochloride
Manufacturers' Codes: R-39209
Trademarks: Rapifen (Janssen-Cilag); Alfenta (Janssen)
Molecular Formula: C21H32N6O3.HCl.H2O
Molecular Weight: 470.99
Percent Composition: C 53.55%, H 7.49%, N 17.84%, O 13.59%, Cl 7.53%
Properties: Crystals from 2-propanone, mp 140.8° (Janssens, 1979); also reported as crystals from acetone, mp 138.4° (Janssens, 1986). Sol in water. LD50 in rats, dogs (mg/kg): 47.5, 20 i.v. (Niemegeers, Janssen).
Melting point: mp 140.8° (Janssens, 1979); mp 138.4° (Janssens, 1986)
Toxicity data: LD50 in rats, dogs (mg/kg): 47.5, 20 i.v. (Niemegeers, Janssen)
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic).
Therap-Cat-Vet: Analgesic (narcotic).
Keywords: Analgesic (Narcotic). |