Title: Vernamycin B
CAS Registry Number: 9040-14-6
Literature References: Group of peptide lactones produced by Streptomyces loidensis: Donovick et al., US 2990325 (1961 to Olin Mathieson). Antimicrobial antibiotic structurally similar to virginiamycin S1: Bodanszky, Ondetti, Antimicrob. Agents Chemother. 1963, 360. Identity with pristinamycins: Preud'homme et al., Bull. Soc. Chim. Fr. 1968, 585. Nomenclature: Crooy, De Neys, J. Antibiot. 25, 371 (1972).
Properties: Crystals, dec 130-135°. [a]D25 -72°. uv max (methanol): 230 nm (E1%1cm 590). Sol in methanol, ethanol, isopropanol, butanol, acetone, methyl ethyl ketone, ethyl acetate, amyl acetate, ether, dioxane, dimethylformamide, benzene, acetic acid; slightly sol in water, hexane.
Optical Rotation: [a]D25 -72°
Absorption maximum: uv max (methanol): 230 nm (E1%1cm 590)
Derivative Type: Vernamycin Ba see Mikamycin B
Derivative Type: Vernamycin Bb
CAS Registry Number: 57206-54-9
Additional Names: 4-[N-Methyl-4-(methylamino)-L-phenylalanine]virginiamycin S1; ostreogrycin B2; pristinamycin IB
Derivative Type: Vernamycin Bg
CAS Registry Number: 28979-74-0
Additional Names: 2-D-Alanine-4-[4-(dimethylamino)-N-methyl-L-phenylalanine]virginiamycin S1; ostreogrycin B1; pristinamycin IC
Derivative Type: Vernamycin Bd
CAS Registry Number: 29139-17-1
Additional Names: 2-D-Alanine-4-[N-methyl-4-(methylamino)-L-phenylalanine]virginiamycin S1
Status: This monograph has been retired and is no longer subject to revision or update. |