Title: Valganciclovir
CAS Registry Number: 175865-60-8
CAS Name: L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester
Additional Names: 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropanyl-L-valinate
Molecular Formula: C14H22N6O5
Molecular Weight: 354.36
Percent Composition: C 47.45%, H 6.26%, N 23.72%, O 22.58%
Literature References: Valine ester prodrug of ganciclovir, q.v. Prepn: J. J. Nestor et al., EP 694547; eidem, US 6083953 (1996, 2000 both to Hoffmann-La Roche). HPLC determn in plasma: R. Chan et al., J. Pharm. Biomed. Anal. 21, 647 (1999). Clinical pharmacokinetics in HIV- and CMV-positive patients: F. Brown et al., Clin. Pharmacokinet. 37, 167 (1999); in liver transplant patients: M. D. Pescovitz et al., Antimicrob. Agents Chemother. 44, 2811 (2000). Clinical trial in cytomegalovirus retinitis: D. F. Martin et al., N. Engl. J. Med. 346, 1119 (2002).
Derivative Type: Hydrochloride
CAS Registry Number: 175865-59-5
Manufacturers' Codes: Ro-107-9070/194; RS-79070-194
Trademarks: Cymeval (Roche); Valcyte (Roche)
Molecular Formula: C14H22N6O5.HCl
Molecular Weight: 390.82
Percent Composition: C 43.02%, H 5.93%, N 21.50%, O 20.47%, Cl 9.07%
Properties: Crystals from water + isopropanol, undergoes phase change at 142°; dec 175°.
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones. |