Title: Telomycin
CAS Registry Number: 19246-24-3
Molecular Formula: C59H77N13O19
Molecular Weight: 1272.32
Percent Composition: C 55.70%, H 6.10%, N 14.31%, O 23.89%
Literature References: Polypeptide antibiotic produced by Streptomyces spp. from Florida soil: Misiek et al., Antibiot. Annu. 1957-1958, 852. Structure: Sheehan et al., J. Am. Chem. Soc. 85, 2867 (1963); 90, 462 (1968). NMR spectrum and conformation: Kumar, Urry, Biochemistry 12, 3811, 4392 (1973). Antibacterial spectrum: A. Gourevitch et al., Antibiot. Annu. 1957-1958, 856. Pharmacology: D. E. Tisch et al., ibid. 863.
Properties: Amorphous, gray solid. [a]D28 -133° (c = 1 in 2:1 methanol-water). uv max (ethanol:water, 2:1): 222.5, 277, 290, 339 nm (e 63732; 13746; 11890; 22058). Minimum soly in water at pH 3.0 to 3.3 = 4 mg/ml. Maximum soly is above pH 8.5 = >150 mg/ml. Soly in 10% sodium chloride soln less than 1 mg/ml. Moderately sol in methanol, ethanol. Very slightly sol in acetone, ethyl acetate. Insol in ether, chloroform, hydrocarbons. Aq solns are stable to heat. LD50 in mice (mg/kg): >1000 orally, i.v., i.p., i.m. (Tisch).
Optical Rotation: [a]D28 -133° (c = 1 in 2:1 methanol-water)
Absorption maximum: uv max (ethanol:water, 2:1): 222.5, 277, 290, 339 nm (e 63732; 13746; 11890; 22058)
Toxicity data: LD50 in mice (mg/kg): >1000 orally, i.v., i.p., i.m. (Tisch) |