Title: Tacalcitol
CAS Registry Number: 57333-96-7
CAS Name: (1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol
Additional Names: 1a,24(R)-dihydroxycholecalciferol; 1a,24R-dihydroxyvitamin D3
Manufacturers' Codes: TV-02
Trademarks: Bonealfa (Teijin); Curatoderm (Merck KGaA)
Molecular Formula: C27H44O3
Molecular Weight: 416.64
Percent Composition: C 77.83%, H 10.64%, O 11.52%
Literature References: Bioactive, synthetic vitamin D3 analog; exhibits antiproliferative effect on keratinocytes. Prepn: T. Takeshita et al., DE 2526981; eidem, US 4022891 (1976, 1977 both to Teijin); M. Morisaki et al., J. Chem. Soc. Perkin Trans. 1 1975, 1421; K. Ochi et al., ibid. 1979, 165. Pharmacology: T. Matsunaga et al., J. Dermatol. 17, 135 (1990). Clinical evaluation in psoriasis: M. J. P. Gerritsen et al., Br. J. Dermatol. 131, 57 (1994). Review: M. Nishimura et al., Eur. J. Dermatol. 3, 255-261 (1993).
Properties: White solid. uv max (ethanol): 265 nm.
Absorption maximum: uv max (ethanol): 265 nm
Therap-Cat: Antipsoriatic.
Keywords: Antipsoriatic. |