Title: Satumomab
CAS Registry Number: 144058-40-2
CAS Name: Anti-(human tumor-associated glycoprotein 72) immunoglobulin G1 (mouse monoclonal B72.3 g1-chain) disulfide with mouse monoclonal B72.3 light chain, dimer
Additional Names: B72.3; CYT-099
Literature References: Murine monoclonal antibody that targets a high molecular weight tumor-associated glycoprotein, TAG-72, expressed on the surface of certain human colon, breast and ovarian carcinoma cell lines. Prepn and characterization of MAb: D. Colcher et al., Proc. Natl. Acad. Sci. USA 78, 3199 (1981); J. Schlom et al., US 4612282 (1986 to USA Secy. Dept. Health Human Services). Pharmacokinetics of 111In labeled MAb: B. A. Brown et al., Cancer Res. 47, 1149 (1987). Clinical studies of immunoscintigraphy in colorectal cancer: B. D. Collier et al., Radiology 185, 179 (1992); in ovarian cancer: E. A. Surwit et al., Gynecol. Oncol. 48, 285 (1993). Review of prepn and diagnostic use: R. T. Maguire et al., Cancer 72, 3453-3462 (1993). Book: Diagnosis of Colorectal and Ovarian Carcinoma, R. T. Maguire, D. Van Nostrand, Eds. (Marcel Dekker, Inc., New York, 1992) 237 pp.
Derivative Type: Indium 111In satumomab pendetide
CAS Registry Number: 138955-27-8
Additional Names: 111In-CYT-103; monoclonal antibody B72.3-GYK-DTPA-In-111; B72.3-glycyl-tyrosyl-N-e-diethylenetriaminepentaacetic acid-In-111
Trademarks: OncoScint (Cytogen)
Therap-Cat: 111In-labeled form as diagnostic aid (radioactive tumor-targeting agent). |