Title: Rofecoxib
CAS Registry Number: 162011-90-7
CAS Name: 4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Manufacturers' Codes: MK-0966
Trademarks: Vioxx (Merck & Co.)
Molecular Formula: C17H14O4S
Molecular Weight: 314.36
Percent Composition: C 64.95%, H 4.49%, O 20.36%, S 10.20%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: Y. Ducharme et al., WO 9500501; eidem, US 5474995 (both 1995 to Merck Frosst). HPLC determn in plasma: C. M. Chavez-Eng et al., J. Chromatogr. B 748, 31 (2000). Enzyme inhibition and clinical evaluation in dental pain: E. W. Ehrich et al., Clin. Pharmacol. Ther. 65, 336 (1999). Evaluation of risk of gastrointestinal effects in patients with osteoarthritis: M. J. Langman et al., J. Am. Med. Assoc. 282, 1929 (1999); with rheumatoid arthritis: C. Bombardier et al., N. Engl. J. Med. 343, 1520 (2000). Review of pharmacology and clinical experience: A. J. Matheson, D. P. Figgitt, Drugs 61, 833-865 (2001).
Properties: White to off-white to light yellow powder. Sparingly sol in acetone; slightly sol in methanol, isopropyl acetate; very slightly sol in ethanol. Practically insol in octanol; insol in water.
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Cyclooxygenase-2 Selective Inhibitor; Anti-inflammatory (Nonsteroidal); Analgesic (Non-Narcotic). |