Title: Rimazolium Metilsulfate
CAS Registry Number: 28610-84-6
CAS Name: 3-(Ethoxycarbonyl)-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium methyl sulfate
Additional Names: 3-carboxy-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium methyl sulfate, ethyl ester; 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazole methyl sulfate
Manufacturers' Codes: MZ-144; MZ-0780; Ro-11-780
Trademarks: Dolcuran (Szabo); Probon (Chinoin); Probonal (Medipolar); Rimagina (Medipolar)
Molecular Formula: C14H22N2O7S
Molecular Weight: 362.40
Percent Composition: C 46.40%, H 6.12%, N 7.73%, O 30.90%, S 8.85%
Literature References: Prepn: Z. Mészáros et al., HU Teljes 519 (1970 to Chinoin), C.A. 74, 42374h (1971); eidem, Arzneim.-Forsch. 22, 815 (1972). Anti-inflammatory and analgesic effects in animals: K. Gyires et al., Drugs Exp. Clin. Res. 11, 493 (1985). Clinical analgesic effect: H. Graber, Int. J. Clin. Pharmacol. Ther. Toxicol. 6, 354 (1972); M. Haataja et al., Curr. Ther. Res. 22, 784 (1977). Series of articles on pharmacology, pharmacodynamics and toxicology: Arzneim.-Forsch. 21, 717-738 (1971). Toxicity data: J. Knoll et al., ibid. 719.
Properties: White crystals, mp 165-166°. uv max: 336, 258 nm (e 3630, 27500). Readily sol in water. LD50 in rats (mg/kg): 220 i.v.; 720 i.p.; 790 s.c.; 1600 orally (Knoll).
Melting point: mp 165-166°
Absorption maximum: uv max: 336, 258 nm (e 3630, 27500)
Toxicity data: LD50 in rats (mg/kg): 220 i.v.; 720 i.p.; 790 s.c.; 1600 orally (Knoll)
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic). |