Title: Orazamide
CAS Registry Number: 2574-78-9
CAS Name: 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid compd with 5-amino-1H-imidazole-4-carboxamide (1:1)
Additional Names: 5-aminoimidazole-4-carboxamide orotate; orotic acid compd with 5(or 4)-aminoimidazole-4(or 5)-carboxamide (1:1); 4-amino-5-imidazolecarboxamide orotate; AICA orotate
Trademarks: Aicamin (Crinos); Aicorat (Mack, Illert.)
Molecular Formula: C9H10N6O5
Molecular Weight: 282.21
Percent Composition: C 38.30%, H 3.57%, N 29.78%, O 28.35%
Literature References: Prepn: FR 1351141; Haraoka, Kamiya, US 3271398 (1964, 1966 both to Fujisawa). Pharmacology and toxicology: Tamura, Shibayama, Yakugaku Kenkyu 35, 94 (1963), C.A. 64, 2652h (1966); Hashimoto, J. Vitaminol. 13, 9, 19 (1967).
Derivative Type: Dihydrate
Properties: Crystals, dec 284-285°. LD50 in mice (g/kg): 0.6 i.p.; >4.0 orally (Tamura, Shibayama).
Toxicity data: LD50 in mice (g/kg): 0.6 i.p.; >4.0 orally (Tamura, Shibayama)
Therap-Cat: Hepatoprotectant.
Keywords: Hepatoprotectant. |