Title: Olmesartan
CAS Registry Number: 144689-63-4
CAS Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2¢-(1H-tetrazol-5-yl)[1,1¢-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
Additional Names: (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-(tetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate; olmesartan medoxomil
Manufacturers' Codes: CS-866
Trademarks: Benicar (Sankyo); Olmetec (Sankyo)
Molecular Formula: C29H30N6O6
Molecular Weight: 558.59
Percent Composition: C 62.36%, H 5.41%, N 15.05%, O 17.19%
Literature References: Angiotensin II receptor antagonist. Prepn: H. Yanagisawa et al., EP 503785; eidem, US 5616599 (1992, 1997 both to Sankyo); eidem, J. Med. Chem. 39, 323 (1996). Clinical evaluation in hypertension: K. Püchler et al., J. Hypertens. 15, 1809 (1997). Review: M. Elisaf, Curr. Opin. Cardiovasc. Pulm. Renal Invest. Drugs 2, 378-383 (2000).
Properties: Monoclinic crystals from ethanol, mp 180-182° (dec). Practically insol in water. Sparingly sol in methanol.
Melting point: mp 180-182° (dec)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Biphenyltetrazole Derivatives; Angiotensin II Receptor Antagonist. |