Title: Milrinone
CAS Registry Number: 78415-72-2
CAS Name: 1,6-Dihydro-2-methyl-6-oxo-(3,4¢-bipyridine)-5-carbonitrile
Additional Names: 1,2-dihydro-6-methyl-2-oxo-5-(4-pyridinyl)nicotinonitrile
Manufacturers' Codes: Win-47203
Trademarks: Corotrope (Sanofi-Synthelabo); Milrila (Yamanouchi)
Molecular Formula: C12H9N3O
Molecular Weight: 211.22
Percent Composition: C 68.24%, H 4.29%, N 19.89%, O 7.57%
Literature References: Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Prepn: G. Y. Lesher et al., BE 886336; G. Y. Lesher, R. E. Philion, US 4313951 (1981, 1982 both to Sterling). Improved process: B. Singh, US 4413127 (1983 to Sterling); idem, Heterocycles 23, 1479 (1985). Pharmacological profile: A. A. Alousi et al., J. Cardiovasc. Pharmacol. 5, 792, 804 (1983). HPLC determn in body fluids: J. Edelson et al., J. Chromatogr. 276, 456 (1983). Clinical studies in congestive heart failure: C. S. Maskin et al., Circulation 67, 1065 (1983); L. S. Sinoway et al., J. Am. Coll. Cardiol. 2, 327 (1983); D. S. Baim et al., N. Engl. J. Med. 309, 748 (1983).
Properties: Crystals from DMF + water or from ethanol, mp >300°.
Melting point: mp >300°
Derivative Type: Lactate
CAS Registry Number: 100286-97-3
Trademarks: Primacor (Sanofi-Synthelabo)
Line Formula: C12H9N3O.xC3H6O3
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic. |