Title: L-Amino Acid Oxidase
CAS Registry Number: 9000-89-9
Additional Names: LAAO
Literature References: Flavoprotein that catalyzes the oxidative deamination of L-amino acids to the corresponding a-keto acids. Found in microorganisms and in animal tissue, esp in kidney and liver. Occurs also in many snake venoms. Isoln from rat kidney: Blanchard et al., J. Biol. Chem. 161, 583 (1945). Isoln of crystalline enzyme from the venom of the eastern diamondback rattlesnake (Crotalus adamanteus): Wellner, Meister, J. Biol. Chem. 235, 2013 (1960). Structural studies: DeKok, Rawitch, Biochemistry 8, 1405 (1969). Studies on inhibitors: DeKok, Veeger, Biochim. Biophys. Acta 167, 35 (1968). Mechanism of reversible activation-deactivation: C. J. Coles et al., Flavins Flavoproteins, Proc. Int. Symp. 6th 1978, K. Yagi, T. Yamano, Eds. (Japan Sci. Soc. Press, Tokyo, 1980) pp 101-105. Multiple conformational states: D. Wellner, L. A. Lichtenberg, Dev. Biochem. 21, 78 (1982). Review: Meister, Wellner in The Enzymes 7, P. Boyer et al., Eds. (Academic Press, New York, 1963) pp 609-634. |