Title: Iopromide
CAS Registry Number: 73334-07-3
CAS Name: N,N¢-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methyl-1,3-benzenedicarboxamide
Additional Names: N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N-methylisophthalamide; 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-dihydroxypropyl)]diamide
Trademarks: Ultravist (Schering AG)
Molecular Formula: C18H24I3N3O8
Molecular Weight: 791.11
Percent Composition: C 27.33%, H 3.06%, I 48.12%, N 5.31%, O 16.18%
Literature References: Nonionic, injectable radio-contrast medium. Prepn: U. Speck et al., DE 2909439; eidem, US 4364921 (1980, 1982 both to Schering AG). Physicochemical properties and pharmacological profile: W. Muetzel, U. Speck, Am. J. Neuroradiol. 4, 350 (1983); P. Dawson et al., Acta Radiol. Diagn. 25, 253 (1984). Clinical experience: K.-J. Wolf et al., ibid. 24, 55 (1983).
Properties: Colorless solid. Stable in aqueous solutions. Viscosity (cP): 4.8 at 37°; 10.2 at 20° (c = 300 mg iodine/ml). LD50 in mice, rats (g iodine/kg body weight): 16.5, 11.4 i.v. (Muetzel).
Toxicity data: LD50 in mice, rats (g iodine/kg body weight): 16.5, 11.4 i.v. (Muetzel)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |