Title: Iophendylate
CAS Registry Number: 99-79-6
CAS Name: 4-Iodo-i-methylbenzenedecanoic acid ethyl ester
Additional Names: ethyl 10-(p-iodophenyl)undecylate; ethyl 10-(p-iodophenyl)hendecanoate
Molecular Formula: C19H29IO2
Molecular Weight: 416.34
Percent Composition: C 54.81%, H 7.02%, I 30.48%, O 7.69%
Literature References: Chief component of Ethiodan, Mulsopaque (Alcon) , Myodil, Neurotrast, Pantopaque (Lafayette) ; may also contain other isomers including 11-(p-iodophenyl)undecylate. Prepn: W. H. Strain et al., J. Am. Chem. Soc. 64, 1436 (1942); eidem, US 2348231 (1944 to Noned Corp. and Kodak); W. Baker et al., J. Soc. Chem. Ind. 63, 223 (1944). Pharmacology and toxicity: T. B. Steinhausen et al., Radiology 43, 230 (1944). Clinical evaluation of diagnostic use in myelography: G. H. Ramsey et al., ibid. 236. Clinical comparison with metrizamide, q.v., in diagnostic radiology: S. A. Keiffer et al., ibid. 129, 695 (1978). Evaluation of use in MR imaging of the spine: I. F. Braun et al., Am. J. Neuroradiol. 7, 997 (1986); A. K. Anand et al., Comput. Radiol. 11, 165 (1987).
Properties: Viscous liquid. Darkens slowly in air. d2020 1.240-1.263. nD25 1.5230-1.5280. Saponif equiv 395-420. Very slightly sol in water. Freely sol in alcohol, benzene, chloroform, ether. LD50 in mice, rats (g/kg): 4.6, 19 i.p. (Steinhausen).
Index of refraction: nD25 1.5230-1.5280
Density: d2020 1.240-1.263
Toxicity data: LD50 in mice, rats (g/kg): 4.6, 19 i.p. (Steinhausen)
Therap-Cat: Diagnostic aid (radiopaque medium).
Therap-Cat-Vet: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |