Title: Flurogestone Acetate
CAS Registry Number: 2529-45-5
CAS Name: (11b)-17-(Acetyloxy)-9-fluoro-11-hydroxypregn-4-ene-3,20-dione
Additional Names: 9-fluoro-11b,17-dihydroxypregn-4-ene-3,20-dione-17-acetate; 17a-acetoxy-9a-fluoro-11b-hydroxyprogesterone; 9-fluoro-11b,17-dihydroxyprogesterone 17-acetate; flugestone acetate
Manufacturers' Codes: SC-9880
Trademarks: Chronogest (Intervet); Cronolone (Searle); Synchronate
Molecular Formula: C23H31FO5
Molecular Weight: 406.49
Percent Composition: C 67.96%, H 7.69%, F 4.67%, O 19.68%
Literature References: Prepn: Bergstrom et al., J. Am. Chem. Soc. 81, 4432 (1959); Bergstrom, Dodson; Bergstrom, Nicholson, US 2892851; US 2963498 (1959, 1960 to Searle).
Properties: Crystals from benzene + petr ether, or ethyl acetate + petr ether, mp 266-269°. [a]D +77.6° (in chloroform). uv max (methanol): 238 nm (e 17500).
Melting point: mp 266-269°
Optical Rotation: [a]D +77.6° (in chloroform)
Absorption maximum: uv max (methanol): 238 nm (e 17500)
NOTE: Component of Syncro-Mate (Searle) .
Therap-Cat: Progestogen.
Therap-Cat-Vet: Progestogen. Estrus regulation.
Keywords: Progestogen. |