Title: Ferric Ammonium Citrate
CAS Registry Number: 1185-57-5
CAS Name: 2-Hydroxy-1,2,3-propanetricarboxylic acid ammonium iron (3+) salt
Additional Names: ammonium ferric citrate; iron(III) ammonium citrate
Trademarks: FerriSeltz (Otsuka)
Literature References: Compounds of NH3, iron, and citric acid of undetermined formula and structure. Prepn: H. J. Kruse, H. C. Mounce, US 2644828 (1953 to Mallinckrodt). ESR characterization of green and brown forms: R. A. Uphaus, M. I. Blake, Naturwissenschaften 68, 270 (1981). Decomposition study: G. A. M. Hussein, Powder Technol. 80, 265 (1994). Use in prevention of anemia in pigs: B. G. Harmon et al., J. Anim. Sci. 26, 1051 (1967). Bioavailability: N. P. Wong et al., Nutr. Rep. Int. 29, 135 (1984). Clinical evaluation in iron deficiency anemia: M. Taniguchi et al., J. Nutr. Sci. Vitaminol. 37, 161 (1991); of use as an MRI contrast agent: S. Hirohashi et al., Magn. Reson. Imaging 12, 837 (1994).
Properties: Two forms exist. The brown hydrated form exists as garnet-red transparent scales or granules, or brownish-yellow powder, and contains ~9% NH3, 16.5-18.5% Fe, and ~65% hydrated citric acid. The green hydrated form exists as green transparent, deliquesc scales, granules, or powder, and contains ~7.5% NH3, 14.5-16% Fe, and ~75% hydrated citric acid. Very sol in water. Insol in alcohol. Reduced to ferrous salt by light. Keep well closed and protected from light.
Use: For blueprints; in photography.
Therap-Cat: Hematinic.
Therap-Cat-Vet: In iron deficiency anemia.
Keywords: Hematinic. |