Title: Factor VII
CAS Registry Number: 9001-25-6
CAS Name: Blood-coagulation factor VII
Additional Names: proconvertin; co-thromboplastin; serum prothrombin conversion accelerator; SPCA
Literature References: Enzyme which, in conjunction with tissue factor and Ca2+ ions initiates the activation of factor X, q.v. Isoln from human plasma or serum: Fantt, Osborn, Thromb. Diath. Haemorrh. 8, 286 (1962); from bovine plasma: J. Jesty, Y. Nemerson, J. Biol. Chem. 249, 509 (1974). Separation from factor X by DEAE cellulose: Hougie, Bunting, in New Blood Clotting Factors, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1960) pp 40-42. Purification and structure of bovine factor VII: J. Jesty, Y. Nemerson, J. Biol. Chem. 249, 509 (1974); R. Radcliffe, Y. Nemerson, ibid. 250, 388 (1975); eidem, Methods Enzymol. 45B, 49 (1976). Its deficiency results in retarded prothrombin conversion and an elevated one-stage prothrombin time: Alexander in Thrombolytic Activity and Related Phenomena, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1961) pp 392-402. Factor VII deficiency is associated with severe liver disease, vitamin K deficiency and broad spectrum antibiotic therapy, or may follow anticoagulant coumarin therapy. |