Title: DPQ
CAS Registry Number: 129075-73-6
CAS Name: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
Molecular Formula: C18H26N2O2
Molecular Weight: 302.41
Percent Composition: C 71.49%, H 8.67%, N 9.26%, O 10.58%
Literature References: Competitive inhibitor of poly (ADP-ribose)polymerase (PARP). Prepn: M. J. Suto et al., EP 355720; eidem, US 5177075 (1990, 1993 both to Warner-Lambert). Use and effects as inhibitior: M. J. L. Eliasson et al., Nat. Med. 3, 1089 (1997); K. Takahashi et al., Brain Res. 829, 46 (1999).
Properties: Crystals from water, mp 107-109°. Water soluble.
Melting point: mp 107-109°
Use: Reagent for inhibition of PARP. |