Title: Diperodon Hydrochloride
CAS Registry Number: 537-12-2
CAS Name: 3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate) (ester) monohydrochloride
Additional Names: 3-piperidino-1,2-propanediol dicarbanilate hydrochloride; 3-(1-piperidyl)-1,2-propanediol dicarbanilate hydrochloride; di(phenylurethan) of 1-piperidinepropane-2,3-diol hydrochloride
Trademarks: Diothane Hydrochloride (HMR); Proctodon (Rowell)
Molecular Formula: C22H28ClN3O4
Molecular Weight: 433.93
Percent Composition: C 60.89%, H 6.50%, Cl 8.17%, N 9.68%, O 14.75%
Literature References: Prepn: T. H. Rider, J. Am. Chem. Soc. 52, 2115 (1930); idem, US 2004132 (1935). Stability of solns: E. S. Cook, T. H. Rider, J. Am. Pharm. Assoc. 26, 222 (1937). Pharmacology: eidem, J. Pharmacol. 64, 1 (1938). X-ray crystallographic study: R. C. Sullivan, K. P. O'Brien, Bull. Narc. 20, 31 (1968). IR spectra: eidem, ibid. 22, 35 (1970).
Properties: Crystals. Bitter taste, followed by a sense of numbness. Stable in air at ordinary temps. Dec 195-200°. Sol in alcohol. Slightly sol in water (1:100), acetone and ethyl acetate. The aq soln is faintly acid to litmus. Extemporaneously prepd aq solns should be used promptly to avoid precipitation of the free base by traces of alkali. The soly in water is increased by the addn of sodium chloride. Insol in benzene or ether.
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).
Status: This monograph has been retired and is no longer subject to revision or update. |