Title: DIDS
CAS Registry Number: 53005-05-3
CAS Name: 2,2¢-(1,2-Ethenediyl)bis[5-isothiocyanatobenzenesulfonic acid]
Additional Names: 4,4¢-diisothiocyanato-2,2¢-stilbenedisulfonic acid
Molecular Formula: C16H10N2O6S4
Molecular Weight: 454.52
Percent Composition: C 42.28%, H 2.22%, N 6.16%, O 21.12%, S 28.22%
Literature References: Classic inhibitor of ion transport across biological membranes. Prepn: Z. I. Cabantchik, A. Rothstein, J. Membr. Biol. 10, 311 (1972); of tritated form: S. Ship et al., ibid. 33, 311 (1977). Inhibition of chloride transport: T. Janas et al., Am. J. Physiol. 257, C601 (1989); J.-A. Kim et al., Biochem. Biophys. Res. Commun. 309, 291 (2003); of non-selective cation conductance: A. Diakov et al., Pflugers Arch. Eur. J. Physiol. 442, 700 (2001). Effects of ionic strength and pH on membrane penetration: V. A. Tverdislov et al., Colloids Surfaces B 5, 205 (1995). Mechanism of inhibition in erythrocytes: J. M. Salhany, Blood Cells Mol. Dis. 27, 901 (2001); of cardiac ryanodine receptor: A. P. Hill, R. Sitsapesan, Biophys. J. 82, 3037 (2002).
Properties: White crystalline solid. uv max: 340 nm (e 16000).
Absorption maximum: uv max: 340 nm (e 16000)
Use: Ion channel inhibitor; especially of anion transport. |