Title: Dichlorisone
CAS Registry Number: 7008-26-6
CAS Name: (11b)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione
Additional Names: 9a,11b-dichloro-1,4-pregnadiene-17a,21-diol-3,20-dione; 9a,11b-dichloro analog of prednisolone
Trademarks: Diloderm (Schering); Disoderm (Schering)
Molecular Formula: C21H26Cl2O4
Molecular Weight: 413.33
Percent Composition: C 61.02%, H 6.34%, Cl 17.15%, O 15.48%
Literature References: Prepn: Robinson et al., J. Am. Chem. Soc. 81, 2191 (1959); Gould et al., US 2894963 (1959 to Schering).
Properties: Crystals from acetone, dec 238-241°. [a]D20 +134° (pyridine). uv max (methanol): 237 nm (e 15400).
Optical Rotation: [a]D20 +134° (pyridine)
Absorption maximum: uv max (methanol): 237 nm (e 15400)
Derivative Type: 21-Acetate
CAS Registry Number: 79-61-8
Trademarks: Astroderm (Medix)
Molecular Formula: C23H28Cl2O5
Molecular Weight: 455.37
Percent Composition: C 60.66%, H 6.20%, Cl 15.57%, O 17.57%
Properties: Crystals from acetone, dec 246-253°. [a]D25 +162° (dioxane). uv max (methanol): 237 nm (e 15000).
Optical Rotation: [a]D25 +162° (dioxane)
Absorption maximum: uv max (methanol): 237 nm (e 15000)
Therap-Cat: Antipruritic (topical).
Keywords: Antipruritic. |