Title: Dendrotoxins
CAS Registry Number: 74811-93-1
Additional Names: DTX
Literature References: Family of low molecular weight (~7K) proteins isolated from the venom of mamba snakes. Inhibits voltage-dependent potassium (K+) channels at nanomolar ranges. Characterized by 3 conserved disulfide linkages in a 57-60 amino acid sequence. Isoln from Dendroaspis angusticeps: A. L. Harvey, E. Karlsson, Arch. Pharmacol. 312, 1 (1980). K+-channel blockade: J. V. Halliwell et al., Proc. Natl. Acad. Sci. USA 83, 493 (1986); relative potencies as blockers: D. G. Owen et al., Br. J. Pharmacol. 120, 1029 (1997). NMR and 2° structure of I: M.-F. Foray et al., Eur. J. Biochem. 211, 813 (1993). Syntheses and sequences: M. E. Byrnes et al., Protein Pept. Lett. 1, 239 (1995); H. Nishio et al., Pept. Chem. 34, 105 (1996). Structure-activity study of K: L. A. Smith et al., Biochemistry 36, 7690 (1997). Comparison of neurotoxic effects with apamin, q.v.: G. Lallement et al., Toxicology 104, 47 (1995). Review: A. L. Harvey, Gen. Pharmacol. 28, 7-12 (1997).
Use: Biochemical tool for K+ channels. |