Title: Clentiazem
CAS Registry Number: 96125-53-0
CAS Name: (2S,3S)-3-(Acetyloxy)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Additional Names: (+)-(2S,3S)-8-chloro-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester)
Molecular Formula: C22H25ClN2O4S
Molecular Weight: 448.96
Percent Composition: C 58.85%, H 5.61%, Cl 7.90%, N 6.24%, O 14.25%, S 7.14%
Literature References: Calcium channel blocker; 8-chloro derivative of diltiazem. Prepn: M. Takeda et al., EP 127882; eidem, US 4567175 (1984, 1986 both to Tanabe); H. Inoue et al., J. Med. Chem. 34, 675 (1991). Cardiovascular pharmacology: H. Narita et al., Arzneim.-Forsch. 38, 515 (1988). Clinical pharmacokinetics: A. K. Shah et al., J. Clin. Pharmacol. 33, 354 (1993). Clinical evaluation in hypertension: S. Kawakita et al., Clin. Cardiol. 14, 53 (1991).
Derivative Type: Maleate
CAS Registry Number: 96128-92-6
Manufacturers' Codes: TA-3090
Trademarks: Logna (Tanabe)
Molecular Formula: C22H25ClN2O4S.C4H4O4
Molecular Weight: 565.04
Percent Composition: C 55.27%, H 5.17%, Cl 6.27%, N 4.96%, O 22.65%, S 5.67%
Properties: Crystals from ethanol, mp 160.5-161.5°. [a]D20 +76.5° (c = 1 in methanol).
Melting point: mp 160.5-161.5°
Optical Rotation: [a]D20 +76.5° (c = 1 in methanol)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Calcium Channel Blocker; Benzothiazepines. |