Title: Cetrorelix
CAS Registry Number: 120287-85-6
CAS Name: N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide
Additional Names: Ac-D-Nal(2)1-D-Phe(4Cl)2-D-Pal(3)3-D-Cit6-D-Ala10-LH-RH
Manufacturers' Codes: SB-75
Molecular Formula: C70H92ClN17O14
Molecular Weight: 1431.04
Percent Composition: C 58.75%, H 6.48%, Cl 2.48%, N 16.64%, O 15.65%
Literature References: Decapeptide LH-RH antagonist. Prepn: A. V. Schally, S. Bajusz, EP 299402 (1989 to Asta); eidem, US 4800191 (1989); S. Bajusz et al., Int. J. Pept. Protein Res. 32, 425 (1988). Structural study: A. Müller et al., ibid. 43, 264 (1994). HPLC determn in plasma: H. H. Raffel et al., J. Chromatogr. B 653, 102 (1994). Pharmacology: T. Reissmann et al., Eur. J. Cancer 32A, 1574 (1996). Clinical evaluation in prostatic cancer: D. Gonzalez-Barcena et al., Urology 45, 275 (1995); in assisted fertilization: C. Albano et al., Fertil. Steril. 67, 917 (1997).
Derivative Type: Acetate
CAS Registry Number: 145672-81-7
Manufacturers' Codes: D-20761
Trademarks: Cetrotide (Serono)
Properties: Sol in water.
Therap-Cat: Antineoplastic (hormonal). In treatment of infertility.
Keywords: Antineoplastic (Hormonal); LH-RH Analogs; LH-RH Antagonist. |