Title: Carbromal
CAS Registry Number: 77-65-6
CAS Name: N-(Aminocarbonyl)-2-bromo-2-ethylbutanamide
Additional Names: (a-bromo-a-ethylbutyryl)urea; (a-bromo-a-ethylbutyryl)carbamide; bromodiethylacetylurea; bromodiethylacetylcarbamide
Trademarks: Tildin; Adalin (Bayer); Planadalin; Diacid (Daro); Addisomnol (Synochem); Bromadal; Uradal; Nyctal
Molecular Formula: C7H13BrN2O2
Molecular Weight: 237.09
Percent Composition: C 35.46%, H 5.53%, Br 33.70%, N 11.82%, O 13.50%
Line Formula: (C2H5)2CBrCONHCONH2
Literature References: Prepd by heating urea (to ~50°) with a-bromo-a-ethylbutyryl bromide (C2H5)2CBrCOBr, see DE 225710 (1910); Frdl. 10, 1160; Chem. Zentralbl. 1910, II, 1008. Patent literature: Slotta, Grundriss der modernen Arzneistoff-Synthese (Stuttgart, 1931); H. P. Kaufmann, Arzneimittel-Synthese (Berlin, 1953).
Properties: Crystals, mp 116-119°. One gram dissolves in about 3000 ml water, 18 ml alcohol, 3 ml chloroform, 14 ml ether. Very sol in boiling alcohol; dissolves in concd sulfuric, nitric and hydrochloric acids, from which it is precipitated on dilution with water. Dissolved by solns of alkali hydroxides.
Melting point: mp 116-119°
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Acylic Ureides. |