Title: Capecitabine
CAS Registry Number: 154361-50-9
CAS Name: 5¢-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Additional Names: [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]carbamic acid pentyl ester; pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihyro-2-oxo-4-pyrimidinecarbamate
Manufacturers' Codes: Ro-9-1978
Trademarks: Xeloda (Roche)
Molecular Formula: C15H22FN3O6
Molecular Weight: 359.35
Percent Composition: C 50.14%, H 6.17%, F 5.29%, N 11.69%, O 26.71%
Literature References: Orally active fluoropyrimidine. Prodrug of doxifluridine, q.v., designed to be metabolized to 5-fluorouracil, q.v., at the tumor site. Prepn: M. Arasaki et al., EP 602454; eidem, US 5472949 (1994, 1995 both to Hoffmann-La Roche). Metabolism by tumor enzymes: T. Ishikawa et al., Cancer Res. 58, 685 (1998). Clinical comparison with i.v. fluorouracil in colorectal cancer: P. M. Hoff et al., J. Clin. Oncol. 19, 2282 (2001); E. Van Cutsem et al., ibid. 4097. Review of pharmacology and clinical experience: J. K. McGavin, K. L. Goa, Drugs 61, 2309-2326 (2001).
Properties: Crystals from ethyl acetate, mp 110-121°. Soly in water (20°): 26 mg/ml.
Melting point: mp 110-121°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs. |