Title: Bromisovalum
CAS Registry Number: 496-67-3
CAS Name: N-(Aminocarbonyl)-2-bromo-3-methylbutanamide
Additional Names: (a-bromoisovaleryl)urea; 2-monobromoisovalerylurea; a-bromo-b-dimethylpropanoylurea; bromvaletone; B.V.U.
Trademarks: Bromural (Knoll); Bromisoval; Uvaleral; Bromuvan; Somnurol (Synochem); Brovalurea; Dormigene (Pharmacobel); Isobromyl (Clin-Comar-Byla); Alluval (Berlin-Chemie); Pivadorm (Specia)
Molecular Formula: C6H11BrN2O2
Molecular Weight: 223.07
Percent Composition: C 32.31%, H 4.97%, Br 35.82%, N 12.56%, O 14.34%
Line Formula: (CH3)2CHCHBrCONHCONH2
Literature References: Prepn from urea and a-bromoisovaleryl bromide: US 914518 (1909). Toxicity: R. I. Mrongovius et al., Clin. Exp. Pharmacol. Physiol. 3, 443 (1976).
Properties: Practically tasteless needles, mp 147-149°. Sublimes. Slightly sol in cold water, but freely sol in hot water. Readily sol in alcohol, ether and in alkaline solns. LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius).
Melting point: mp 147-149°
Toxicity data: LD50 in male mice (mmoles/kg): 3.25 i.p. (Mrongovius)
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Acylic Ureides. |