Title: Batroxobin
CAS Registry Number: 9039-61-6
CAS Name: Bothrops atrox serine proteinase
Additional Names: Bothrops venom proteinase
Trademarks: Botropase (Ravizza); Defibrase (Gerot)
Literature References: Thrombin-like enzyme from the venom of Bothrops atrox (Linn.), a pit viper found in several varieties in Southern and Central America. Prepn of conc extract from B. jararaca venom and coagulative properties: D. von Klobusitzky, Arch. Exp. Pathol. Pharmakol. 179, 204 (1935). The enzyme from B. atrox venom is hemostatic at low doses and acts as a blood anti-coagulant at higher doses. Composition and manuf: E. E. Percs et al., DE 2201993; eidem, US 3849252 (1972, 1974 both to Pentapharm). Studies on the subunit structure of fibrin produced by batroxobin: P. Mattock, M. P. Esnouf, Nature New Biol. 233, 277 (1971). In vitro blood-clotting activity: K. O. Wik et al., Br. J. Haematol. 23, 37 (1972). Electron microscopic study: S. Ishimaru et al., Thromb. Haemostasis 45, 276 (1981). Clinical pharmacology: K. Fukutake et al., Nippon Ketsueki Gakkai Zasshi 44, 1178 (1981), C.A. 96, 62775x (1982). Review of characterization, properties: K. G. Stocker, G. H. Barlow, Aktuel. Probl. Angiol. 26, 45-62 (1975).
Properties: Rectangular crystals. Sol in physiological saline. Practically insol in distilled water. Forms complexes with phenol and phenol derivs that are practically insol in water.
Derivative Type: Mixture with factor-X activator
Additional Names: Hemocoagulase
Trademarks: Reptilase (Knoll)
Therap-Cat: Hemostatic.
Keywords: Hemostatic. |