Title: Azintamide
CAS Registry Number: 1830-32-6
CAS Name: 2-[(6-Chloro-3-pyridazinyl)thio]-N,N-diethylacetamide
Additional Names: N,N-diethyl-2-[6-(3-chloropyridazinyl)thio]acetamide; N,N-diethyl-2-[6-(3-chloropyridazinyl)mercapto]acetamide; (3-chloro-6-pyridazinylthio)acetic acid diethylamide
Manufacturers' Codes: ST-9067
Trademarks: Ora-Gallin purum (Nycomed)
Molecular Formula: C10H14ClN3OS
Molecular Weight: 259.76
Percent Composition: C 46.24%, H 5.43%, Cl 13.65%, N 16.18%, O 6.16%, S 12.34%
Literature References: Prepn: E. Kloimstein et al., Arzneim.-Forsch. 14, 261 (1964); eidem, DE 1188604 (1965 to Lentia). Pharmacology and acute toxicity: H. Stormann, Arzneim.-Forsch. 14, 266 (1964). Toxicology: I. Lindner et al., ibid. 271. Clinical pharmacology: G. Hitzenberger, ibid. 279. Comprehensive description: E. M. Abdel-Moety, H. A. Al-Khamees, Anal. Profiles Drug Subs. 18, 1-32 (1989).
Properties: Colorless, bitter tasting microcrystals, mp 97-98°. Freely sol in benzene, chloroform, ethyl acetate, acetone. Sol in water 0.5%. uv max (ethanol): 316, 306, 258 nm (e 1.404 ´ 103, 1.492 ´ 103, 1.421 ´ 104). LD50 in mice, rats (g/kg): 2.34, 1.55 orally (Stormann).
Melting point: mp 97-98°
Absorption maximum: uv max (ethanol): 316, 306, 258 nm (e 1.404 ´ 103, 1.492 ´ 103, 1.421 ´ 104)
Toxicity data: LD50 in mice, rats (g/kg): 2.34, 1.55 orally (Stormann)
Therap-Cat: Choleretic.
Keywords: Choleretic. |