Title: Aurothioglucose
CAS Registry Number: 12192-57-3
CAS Name: (1-Thio-D-glucopyranosato-O2,S1)gold
Additional Names: (1-D-glucosylthio)gold; gold thioglucose
Trademarks: Aureotan (Byk Gulden); Solganal (Schering)
Molecular Formula: C6H11AuO5S
Molecular Weight: 392.18
Percent Composition: C 18.38%, H 2.83%, Au 50.22%, O 20.40%, S 8.18%
Literature References: Disease modifying antirheumatic drug (DMARD). Prepn: Lebeau-Janot, Traité Pharm. Chim. II, 661 (1956). Induction of obesity in exptl animals: A. F. Debons et al., Fed. Proc. 36, 143 (1977). Clinical comparison with auranofin, q.v., in rheumatoid arthritis: P. L. C. M. Van Riel et al., Clin. Rheumatol. 5, 359 (1986); P. E. Prete et al., Clin. Rheumatol. 13, 60 (1994).
Properties: Yellow crystals. Slight mercaptan-like odor. Sol in water with decompn; slightly sol in propylene glycol. Practically insol in acetone, alcohol, chloroform, ether.
Use: To produce obesity in exptl animals.
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic. |