Title: Anandamide
CAS Registry Number: 94421-68-8
CAS Name: (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
Additional Names: arachidonylethanolamide; N-(2-hydroxyethyl)arachidonamide
Molecular Formula: C22H37NO2
Molecular Weight: 347.53
Percent Composition: C 76.03%, H 10.73%, N 4.03%, O 9.21%
Literature References: Endogenous ligand for the mammalian cannabinoid receptor; derivative of arachidonic acid, q.v. Name coined from the Sanskrit word "ananda," meaning bliss. Identification in pig brain: W. A. Devane et al., Science 258, 1946 (1992). Identification in chocolate and cocoa: E. di Tomaso et al., Nature 382, 677 (1996). Pharmacology: P. B. Smith et al., J. Pharmacol. Exp. Ther. 270, 219 (1994). Biosynthetic studies: W. A. Devane, J. Axelrod, Proc. Natl. Acad. Sci. USA 91, 6698 (1994); V. Di Marzo et al., Nature 372, 686 (1994). LC/MS/MS determn and distribution in human tissues: C. C. Felder et al., FEBS Lett. 393, 231 (1996). Review: V. Di Marzo, A. Fontana, Prostaglandins Leukotrienes Essent. Fatty Acids 53, 1-11 (1995). |