Title: Amrinone
CAS Registry Number: 60719-84-8
CAS Name: 5-Amino-(3,4¢-bipyridin)-6(1H)-one
Additional Names: 3-amino-5-(4-pyridinyl)-2(1H)-pyridinone
Manufacturers' Codes: Win-40680
Trademarks: Cartonic (Yamanouchi); Inocor (Sanofi Winthrop); Vesistol (Inverni); Wincoram (Sanofi Winthrop)
Molecular Formula: C10H9N3O
Molecular Weight: 187.20
Percent Composition: C 64.16%, H 4.85%, N 22.45%, O 8.55%
Literature References: Selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. Prepn: G. Y. Lesher, C. J. Opalka, US 4004012; US 4072746 (1977, 1978 both to Sterling). Clinical hemodynamic assessment: J. R. Benotti et al., N. Engl. J. Med. 21, 1373 (1978). Review of pharmacology and clinical efficacy: A. Ward et al., Drugs 26, 468 (1983); M. B. Bottorff et al., Pharmacotherapy 5, 227-237 (1985). Series of articles on pharmacology, mechanism of action and clinical experience: J. Cardiothorac. Anesth. 6, Suppl. 2, 1-57 (1989).
Properties: Crystals from DMF, mp 294-297° (dec).
Melting point: mp 294-297° (dec)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic. |