Title: Ammonium Tetrathiomolybdate
CAS Registry Number: 15060-55-6; 16330-92-0 (tetrathiomolybdate(2-))
CAS Name: (T-4)-Diammonium tetrathioxomolybdate(2-)
Molecular Formula: H8MoN2S4
Molecular Weight: 260.28
Percent Composition: H 3.10%, Mo 36.86%, N 10.76%, S 49.28%
Line Formula: (NH4)2MoS4
Literature References: Forms a complex with copper in vivo, blocking intestinal absorption. Prepn: G. Krüss, Ann. 225, 1 (1884); and characterization: J. W. McDonald et al., Inorg. Chim. Acta 72, 205 (1983). Thermal decomposition study: R. I. Walton et al., Chem. Mater. 10, 3737 (1998). Mechanism of action study: G. N. George et al., J. Am. Chem. Soc. 125, 1704 (2003). Use in treatment of copper poisoning in sheep: W. R. Humphries et al., Vet. Rec. 123, 51 (1988). Clinical evaluation in Wilson's disease: G. J. Brewer et al., Arch. Neurol. 51, 545 (1994); 53, 1017 (1996); 60, 379 (2003). Review of therapeutic potential: G. J. Brewer, J. Cell. Mol. Med. 7, 11-20 (2003).
Properties: uv max (H2O): 241, 316, 467 nm (e 24700, 16750, 11850).
Absorption maximum: uv max (H2O): 241, 316, 467 nm (e 24700, 16750, 11850)
Use: In prepn of molybdenum disulfide, q.v., and other transition metal sulfide clusters.
Therap-Cat: Chelating agent (copper); Wilson's Disease treatment.
Therap-Cat-Vet: Antidote (copper poisoning).
Keywords: Wilson's Disease Treatment; Chelating Agent. |