Title: ADA
CAS Registry Number: 26239-55-4
CAS Name: N-(2-Amino-2-oxoethyl)-N-(carboxymethyl)glycine
Additional Names: N-(2-acetamido)iminodiacetic acid
Molecular Formula: C6H10N2O5
Molecular Weight: 190.15
Percent Composition: C 37.90%, H 5.30%, N 14.73%, O 42.07%
Literature References: One of several zwitterionic N-substituted amino acids known as "Good" buffers. Active in the pH range 6-8. Prepn: G. Schwarzenbach et al., Helv. Chim. Acta 38, 1147 (1955); and description: N. E. Good et al., Biochemistry 5, 467 (1966). Thermodynamic behavior: C. D. McGlothlin, J. Jordan, Anal. Lett. 9, 245 (1976); F. Jumean, J. Indian Chem. Soc. 69, 237 (1992). Use as buffer: Z. Pietrzkowski, W. Korohoda, Folia Histochem. Cytobiol. 26, 143 (1988); as analytical reagent for chromium: C. Baluja-Santos et al., Rev. Roum. Chim. 39, 73 (1994); as chelator: M. C. Steele, J. Pichtel, J. Environ. Eng. 124, 639 (1998).
Properties: Crystals from chloroacetamide, dec 220°. Slightly sol in water. pKa1: <2; pKa2: 2-3; pKa3 when 0.1M (0°): 6.85; (20°): 6.60; (37°): 6.45. DpKa/°C = -0.011.
pKa: pKa1: <2; pKa2: 2-3; pKa3 when 0.1M (0°): 6.85; (20°): 6.60; (37°): 6.45; pKa/°C = -0.011
Use: Buffer for biological systems and chelator for metals. |