Title: Abecarnil
CAS Registry Number: 111841-85-1
CAS Name: 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid 1-methylethyl ester
Additional Names: isopropyl 6-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate; isopropyl 6-(benzyloxy)-4-(methoxymethyl)-b-carboline-3-carboxylate
Manufacturers' Codes: ZK-112119
Molecular Formula: C24H24N2O4
Molecular Weight: 404.46
Percent Composition: C 71.27%, H 5.98%, N 6.93%, O 15.82%
Literature References: Benzodiazepine receptor agonist. Prepn: H. Biere et al., DE 3609699 (1987 to Schering AG), C.A. 108, 21872z (1988). Pharmacology and receptor binding studies: D. N. Stephens et al., J. Pharmacol. Exp. Ther. 253, 334 (1990). Determn in biological samples: W. Krause et al., J. Pharm. Sci. 78, 622 (1989). Clinical pharmacokinetics: W. Krause et al., Xenobiotica 21, 763 (1991). Clinical trial in anxiety: J. C. Ballenger et al., Adv. Biochem. Psychopharmacol. 47, 431 (1992). Series of articles on pharmacology, tolerance and clinical evaluation: Psychopharmacol. Ser. 11, 50-147 (1993).
Properties: Crystals from ethyl acetate, mp 150-151°.
Melting point: mp 150-151°
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic.
Status: This monograph has been retired and is no longer subject to revision or update. |