Title: Tolperisone
CAS Registry Number: 728-88-1
CAS Name: 2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone
Additional Names: 2,4¢-dimethyl-3-piperidinopropiophenone; 1-piperidino-2-methyl-3-(p-tolyl)-3-propanone; 2-methyl-3-piperidino-1-p-tolylpropan-1-one; mydetone
Molecular Formula: C16H23NO
Molecular Weight: 245.36
Percent Composition: C 78.32%, H 9.45%, N 5.71%, O 6.52%
Literature References: Prepn: Nádor et al., HU 144997 (1956); Yokoyama et al., JP 65 20390 (1965 to Eisai). Pharmacology and toxicity: J. Porszasz et al., Acta Physiol. Acad. Sci. Hung. 18, 149 (1960); eidem, Arzneim.-Forsch. 11, 257 (1961).
Derivative Type: Hydrochloride
CAS Registry Number: 3644-61-9
Manufacturers' Codes: N-553
Trademarks: Abbsa (Sanko); Atmosgen (Maruko); Arantoick (Ohta); Besnoline (Kotobuki); Isocalm (Kaken); Kineorl (Showa Shinyaku); Menopatol (Chemiphar); Metosomin (Maruishi); Minacalm (Tobishi); Muscalm (Nippon Kayaku); Mydocalm (Labatec); Naismeritin (Hishiyama); Tolisartine (Kowa)
Molecular Formula: C16H23NO.HCl
Molecular Weight: 281.82
Percent Composition: C 68.19%, H 8.58%, N 4.97%, O 5.68%, Cl 12.58%
Properties: Crystals from methyl ethyl ketone, mp 176-177°. LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961).
Melting point: mp 176-177°
Toxicity data: LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)
Therap-Cat: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal). |