Title: Telenzepine
CAS Registry Number: 80880-90-6
CAS Name: 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinylacetyl)]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Molecular Formula: C19H22N4O2S
Molecular Weight: 370.47
Percent Composition: C 61.60%, H 5.99%, N 15.12%, O 8.64%, S 8.66%
Literature References: Gastric secretion inhibitor; selective muscarinic M1-receptor antagonist. Prepn: V. Figala et al., EP 35519; G. Rainer, US 4381301 (1981, 1983 both to Byk-Gulden). Pharmacology: M. Eltze et al., Eur. J. Pharmacol. 112, 211 (1985). GC-MS determn in serum: E. Sturm, A. Junker, J. Chromatogr. 430, 43 (1988). Clinical pharmacology: W. Londong et al., Gut 28, 888 (1987); R.W. Stockbrügger et al., Z. Gastroenterol. 26, 297 (1988). Comparative clinical trial with ranitidine: B. Simon et al., ibid. 28, 90 (1990).
Properties: Crystals from ethanol, mp 263-264°.
Melting point: mp 263-264°
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Gastric Secretion Inhibitor; Antimuscarinic.
Status: This monograph has been retired and is no longer subject to revision or update. |