Title: Tedisamil
CAS Registry Number: 90961-53-8
CAS Name: 3¢,7¢-Bis(cyclopropylmethyl)spiro[cyclopentane-1,9¢-[3,7]diazabicyclo[3.3.1]nonane]
Molecular Formula: C19H32N2
Molecular Weight: 288.47
Percent Composition: C 79.11%, H 11.18%, N 9.71%
Literature References: Potassium channel blocking bradycardic agent. Prepn: U. Schön et al., DE 3234697; eidem, US 4550112 (1984, 1985 both to Kali-Chemie); and pharmacology: idem et al., J. Med. Chem. 41, 318 (1998). Suppression of the outward transient K+ current in rat myocytes: I. D. Dukes, M. Morad, Am. J. Physiol. 275, H1746 (1989). Toxicity in rats: E. Hayes et al., Pharmacol. Toxicol. 73, 257 (1993). Comparative clinical study in coronary artery disease: V. Mitrovic, et al., Clin. Cardiol. 21, 492 (1998). Clinical study in stable angina: K. M. Fox et al., Heart 83, 167 (2000). Review of pharmacology and clinical development: B. Freestone, G. Y. H. Lip, Expert Opin. Invest. Drugs 13, 151-160 (2004).
Derivative Type: Dihydrochloride
CAS Registry Number: 132523-84-3
Manufacturers' Codes: KC-8857
Molecular Formula: C19H32N2.2HCl
Molecular Weight: 361.39
Percent Composition: C 63.15%, H 9.48%, N 7.75%, Cl 19.62%
Properties: White crystals, mp 195-197°. bp 230° (0.1 Torr). Sol in water.
Melting point: mp 195-197°
Boiling point: bp 230° (0.1 Torr)
Therap-Cat: Antiarrhythmic (class III); antianginal.
Keywords: Antianginal; Bradycardic Agent; Antiarrhythmic; Potassium Channel Blocker. |