Title: Talniflumate
CAS Registry Number: 66898-62-2
CAS Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
Additional Names: phthalidyl 2-(3-trifluoromethylanilino)nicotinate; phthalidyl 2-(a,a,a-trifluoro-m-toluidino)nicotinate
Manufacturers' Codes: BA-7602-06
Trademarks: Somalgen (Bago)
Molecular Formula: C21H13F3N2O4
Molecular Weight: 414.33
Percent Composition: C 60.88%, H 3.16%, F 13.76%, N 6.76%, O 15.45%
Literature References: Prodrug of niflumic acid, q.v. Prepn: BE 858864 (1978 to Bago), C.A. 89, 109104 (1978); S. Bago, US 4168313 (1979). Synthesis and pharmacologic study: M. Los et al., Farmaco Ed. Sci. 36, 372 (1981). HPLC determn in plasma: D.-J. Jang et al., Biomed. Chromatogr. 19, 32 (2005). Review of clinical development as a mucoregulator: D. Knight, Curr. Opin. Invest. Drugs 5, 557-562 (2004).
Properties: White or pale yellow crystalline powder, mp 165-166°. uv max (chloroform): 287, 357 nm (e 25600, 7800). LD50 orally in rats: 12000 mg/kg (Los).
Melting point: mp 165-166°
Absorption maximum: uv max (chloroform): 287, 357 nm (e 25600, 7800)
Toxicity data: LD50 orally in rats: 12000 mg/kg (Los)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives. |