Title: Sulforidazine
CAS Registry Number: 14759-06-9
CAS Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-10H-phenothiazine
Additional Names: 3-(methylsulfonyl)-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine; thioridazine-2-sulfone
Manufacturers' Codes: TPN-12
Trademarks: Imagotan (Sandoz); Inofal (Sandoz)
Molecular Formula: C21H26N2O2S2
Molecular Weight: 402.57
Percent Composition: C 62.65%, H 6.51%, N 6.96%, O 7.95%, S 15.93%
Literature References: Dopamine receptor blocker; metabolite of thioridazine and mesoridazine, q.q.v. Prepn: Renz et al., FR 1363683 and FR 1459476 (1964, 1966, both to Sandoz). Pharmacology: Maruyama et al., C.A. 68, 20799z (1968). Effects on dopaminergic function in comparison with mesoridazine and thioridazine: D. M. Niedzwiecki et al., J. Pharmacol. Exp. Ther. 228, 636 (1984); C. D. Kilts et al., ibid. 231, 334 (1984). Clinical evaluation as antipsychotic: R. Axelsson, Curr. Ther. Res. 21, 587 (1977). HPLC determn in plasma: D. A. Ganes, K. K. Midha, J. Chromatogr. 423, 227 (1987).
Properties: Crystals from acetone, mp 121-123°.
Melting point: mp 121-123°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines. |