Title: Sufentanil
CAS Registry Number: 56030-54-7
CAS Name: N-[4-(Methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidinyl]-N-phenylpropanamide
Additional Names: N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]propionanilide; sufentanyl
Manufacturers' Codes: R-30730
Molecular Formula: C22H30N2O2S
Molecular Weight: 386.55
Percent Composition: C 68.36%, H 7.82%, N 7.25%, O 8.28%, S 8.30%
Literature References: Potent deriv of fentanyl, q.v. Prepn: P. A. J. Janssen, G. H. P. Van Daele, DE 2610228; eidem, US 3998834 (both 1976 to Janssen); G. H. P. Van Daele et al., Arzneim.-Forsch. 26, 1521 (1976). In vitro binding properties to mu-opiate receptor: J. E. Leysen, W. Gommeren, Arch. Int. Pharmacodyn. Ther. 260, 287 (1982); J. E. Leyson et al., Eur. J. Pharmacol. 87, 209 (1983). Analgesic activity and safety assessment: W. F. M. Van Bever et al., Arzneim.-Forsch. 26, 1548 (1976); C. J. E. Niemegeers et al., ibid. 1551. GC determn in biological fluids: R. Woestenborghs et al., J. Chromatogr. 224, 122 (1981); T. J. Gillespie et al., J. Anal. Toxicol. 5, 133 (1981). Radioimmunoassay: M. Michaels et al., J. Pharm. Pharmacol. 35, 86 (1983). Comparison to fentanyl for coronary artery surgery: S. de Lange et al., Anesthesiology 56, 112 (1982). EEG effects in man: J. G. Bovill et al., Br. J. Anaesth. 54, 45 (1982). Review of pharmacokinetics: L. E. Mather, Clin. Pharmacokinet. 8, 422-426 (1983).
Properties: Crystals from petr ether, mp 96.6°. LD50 i.v. in mice: 18.7 mg/kg (Van Bever).
Melting point: mp 96.6°
Toxicity data: LD50 i.v. in mice: 18.7 mg/kg (Van Bever)
Derivative Type: Citrate
CAS Registry Number: 60561-17-3
Manufacturers' Codes: R-33800
Trademarks: Sufenta (Janssen)
Molecular Formula: C22H30N2O2S.C6H8O7
Molecular Weight: 578.67
Percent Composition: C 58.12%, H 6.62%, N 4.84%, O 24.88%, S 5.54%
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic). |