Title: Sermorelin
CAS Registry Number: 86168-78-7
Additional Names: Human growth hormone-releasing factor(1-29)amide; human pancreatic somatoliberin(1-29)amide; GRF(1-29)NH2; hpGRF(1-29)NH2
Manufacturers' Codes: SM-8144
Trademarks: Geref (Serono); Groliberin (Kabi)
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.88
Percent Composition: C 53.30%, H 7.38%, N 18.35%, O 20.01%, S 0.95%
Literature References: Amidated fragment of human somatoliberin, q.v. Characterization of in vitro activity: J. Rivier et al., Nature 300, 276 (1982). Prepn: N. Ling et al., Biochem. Biophys. Res. Commun. 123, 854 (1984); J. E. F. Rivier et al., US 4703035 (1987 to Salk Inst. Biol. Stud.). Clinical pharmacology: M. Losa et al., Klin. Wochenschr. 62, 1140 (1984). Clinical evaluation in growth hormone deficiency: M. B. Ranke et al., Eur. J. Pediatr. 145, 485 (1986); R. Hümmelink et al., Acta Paediatr. Scand. Suppl. 331, 48 (1987). Field trial in pigs and dairy heifers: D. Petitclerc et al., J. Anim. Sci. 65, 996 (1987).
Properties: [a]D20 -63.1° (c = 1 in 30% acetic acid).
Optical Rotation: [a]D20 -63.1° (c = 1 in 30% acetic acid)
Therap-Cat: Growth hormone releasing factor.
Keywords: Growth Hormone Releasing Factor. |