Title: Roxarsone
CAS Registry Number: 121-19-7
CAS Name: 4-Hydroxy-3-nitrophenylarsonic acid
Additional Names: 4-hydroxy-3-nitrobenzenearsonic acid; 3-nitro-4-hydroxyphenylarsonic acid; 2-nitro-1-hydroxybenzene-4-arsonic acid; nitrophenolarsonic acid
Manufacturers' Codes: NSC-2101
Trademarks: Ren-o-sal (Salsbury)
Molecular Formula: C6H6AsNO6
Molecular Weight: 263.04
Percent Composition: C 27.40%, H 2.30%, As 28.48%, N 5.32%, O 36.49%
Literature References: Prepd by treating sodium p-hydroxyphenylarsonate with a mixture of nitric and sulfuric acids at 0°: Benda, Bertheim, Ber. 44, 3446 (1911); DE 224953 C.A. 5, 156 (1911). Toxicity study: Kerr et al., Toxicol. Appl. Pharmacol. 5, 507 (1963). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.
Properties: Tufts of pale-yellow needles or rhombohedral plates from water. Puffs up and deflagrates on heating. Slightly sol in cold water; sol in ~30 parts boiling water; freely sol in methanol, ethanol, acetic acid, acetone, alkalies; sparingly sol in dil mineral acids. Insol in ether, ethyl acetate. Forms mono-, di-, and trisodium salts. LD50 in rats, chickens (mg/kg): 155, 110-123 orally; 66, 34 i.p. (Kerr).
Toxicity data: LD50 in rats, chickens (mg/kg): 155, 110-123 orally; 66, 34 i.p. (Kerr)
Use: Formerly in manuf arsphenamines; as reagent for zirconium.
Therap-Cat-Vet: Control of enteric infections. To improve growth and feed efficiency. |