Title: Practolol
CAS Registry Number: 6673-35-4
CAS Name: N-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide
Additional Names: 4¢-[2-hydroxy-3-(isopropylamino)propoxy]acetanilide; 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol
Manufacturers' Codes: AY-21011; ICI-50172
Trademarks: Dalzic (Zeneca); Eraldin (Zeneca)
Molecular Formula: C14H22N2O3
Molecular Weight: 266.34
Percent Composition: C 63.13%, H 8.33%, N 10.52%, O 18.02%
Literature References: b-Adrenergic blocker. Prepn: Howe, Smith, NL 6512676; eidem, US 3408387 (1966, 1968, to I.C.I.). Synthesis of R(+)-form: Danilewicz, Kemp, J. Med. Chem. 16, 168 (1973). Pharmacological studies: Dunlop, Shanks, Br. J. Pharmacol. Chemother. 32, 201 (1968); Barrett, Postgrad. Med. J. Suppl. 47, 7 (1971). Metabolic studies: Scales, Cosgrove, J. Pharmacol. Exp. Ther. 175, 338 (1970).
Properties: mp 134-136° (BuOAc). Sol in warm isopropanol.
Melting point: mp 134-136° (BuOAc)
Derivative Type: Hydrochloride monohydrate
Properties: mp 140-142°.
Melting point: mp 140-142°
Derivative Type: R(+)-Form
Properties: Crystals from dioxane, mp 130-131.5°. [a]25365 +4.3°, [a]25578 +3.5° (ethanol).
Melting point: mp 130-131.5°
Optical Rotation: [a]25365 +4.3°; [a]25578 +3.5° (ethanol)
Derivative Type: R(+)-Hydrochloride
Properties: [a]25436+26.0°, [a]25578 +14.0°.
Optical Rotation: [a]25436+26.0°; [a]25578 +14.0°
Therap-Cat: Antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic. |