Title: Pildralazine
CAS Registry Number: 64000-73-3
CAS Name: 6-[(2-Hydroxypropyl)methylamino]-3(2H)-pyridazinone hydrazone
Additional Names: 3-hydrazino-6-[(2-hydroxypropyl)methylamino]pyridazine; (±)-1-[(6-hydrazino-3-pyridazinyl)methylamino]-2-propanol; propyldazine; propildazine
Molecular Formula: C8H15N5O
Molecular Weight: 197.24
Percent Composition: C 48.72%, H 7.67%, N 35.51%, O 8.11%
Literature References: Peripheral vasodilator with hypotensive activity; related to hydralazine, q.v. Prepn: G. Pifferi, DE 2154245; idem, US 3769278 (1972, 1973 both to I.S.F.); G. Pifferi et al., J. Med. Chem. 18, 741 (1975). Pharmacology in animals: L. Dorigotti et al., Pharmacol. Res. Commun. 8, 295 (1976); L. Dorigotti et al., Arzneim.-Forsch. 34, 876 (1984); in humans: L. Terzoli et al., Boll. Soc. Ital. Cardiol. 22, 1053 (1977). GLC determn in plasma: P. Ventura et al., J. Chromatogr. 161, 237 (1978). Clinical evaluation in essential hypertension: R. Pellegrini, G. Abbondati, Farmaco Ed. Prat. 32, 19 (1977). Pharmacokinetics and tissue binding: E. Noack et al., Arzneim.-Forsch. 37, 407 (1987).
Derivative Type: Dihydrochloride
CAS Registry Number: 56393-22-7
Manufacturers' Codes: ISF-2123
Trademarks: Atensil
Molecular Formula: C8H15N5O.2HCl
Molecular Weight: 270.16
Percent Composition: C 35.57%, H 6.34%, N 25.92%, O 5.92%, Cl 26.25%
Properties: Crystals from ethanol, mp 206-209° (dec). LD50 in mice, rats (mg/kg): 357, 355 i.p.; 1170, 1230 orally (Dorigotti, 1976).
Melting point: mp 206-209° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 357, 355 i.p.; 1170, 1230 orally (Dorigotti, 1976)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines. |